Investigating the Clinical Diagnosis and Classification of Lymphoma

A clinical lymphoma is a cancer of the lymphatic system, and is classified based on its lineage. The disease is classified according to its morphologic characteristics and immunophenotypic features. A tissue biopsy is considered the gold standard for a diagnosis, and it can provide material for flow cytometry, immunocytochemistry, and FISH studies. The biopsy is also useful for DNA and RNA extraction. An excision biopsy is a better choice for diagnosing a lymphoma in a patient with a small tumor, as it provides more material for a diagnostic test. However, due to its size and processing limitations, the excision biopsy is not suitable for all patients.

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Lymphoma requires aggressive treatment

The classification of lymphomas is complex and requires a hematopathologist’s expertise. It involves the integration of multiple findings and a multiparameter approach. Currently, a patient with a non-Hodgkins lymphoma may have symptoms of a reactive process. This means that a diagnosis of a non-Hodgkin’s lymphoma should be considered aggressive and require aggressive treatment.


In lymphoid neoplasms, patients may be diagnosed with a single lesion or a combination of several lesions. A hematologist can help diagnose a lymphoma using a number of tests. Hematologists will perform multiple exams and analyze the results in order to determine the appropriate treatment. By combining immunophenotypic evaluation with morphological assessment, a clinical diagnosis can be made with a high level of confidence.

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